J David Spence Selected Research

Homocysteine

1/2022	Problem in the Recent American Heart Association Guideline on Secondary Stroke Prevention: B Vitamins to Lower Homocysteine Do Prevent Stroke.
1/2021	Stroke Prevention: Little-Known and Neglected Aspects.
12/2020	Stroke Prevention in Older Adults: Recent Advances.
1/2020	Stroke Prevention: A Lifetime of Lessons.
3/2019	Nutrition and Risk of Stroke.
1/2019	Vitamin B 12 deficiency and hyperhomocysteinaemia in outpatients with stroke or transient ischaemic attack: a cohort study at an academic medical centre.
6/2018	Cardioembolic stroke: everything has changed.
12/2017	Association of homocysteine and smoking with cerebral microemboli in patients with mechanical heart valves: a transcranial Doppler study.
1/2017	Recent advances in preventing stroke recurrence.
1/2017	Rational Medical Therapy Is the Key to Effective Cardiovascular Disease Prevention.

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J David Spence Research Topics

Disease

82	Stroke (Strokes) 01/2022 - 08/2002
39	Atherosclerosis 04/2022 - 08/2002
29	Carotid Stenosis (Carotid Artery Stenosis) 01/2021 - 05/2003
26	Hypertension (High Blood Pressure) 01/2021 - 08/2002
20	Myocardial Infarction 01/2022 - 08/2002
14	Cardiovascular Diseases (Cardiovascular Disease) 04/2022 - 10/2004
14	Ischemic Stroke 01/2022 - 02/2004
13	Carotid Artery Diseases 01/2022 - 08/2002
13	Atrial Fibrillation 12/2020 - 01/2007
10	Pathologic Constriction (Stenosis) 06/2018 - 04/2002
9	Transient Ischemic Attack 01/2022 - 06/2007
9	Insulin Resistance 01/2022 - 12/2005
9	Thrombosis (Thrombus) 10/2016 - 06/2004
8	Renal Insufficiency (Renal Failure) 01/2022 - 01/2016
6	Embolic Stroke 01/2022 - 01/2007
6	Atherosclerotic Plaque (Atheroma) 01/2020 - 11/2003
6	Vascular Diseases (Vascular Disease) 01/2020 - 05/2003
4	Cerebral Hemorrhage 01/2020 - 09/2010
4	Patent Foramen Ovale 01/2019 - 01/2017
4	Hyperaldosteronism (Conn Syndrome) 06/2018 - 05/2010
3	Metabolic Syndrome (Dysmetabolic Syndrome X) 04/2022 - 07/2006
3	Dementia (Dementias) 12/2020 - 01/2013
3	Hemorrhage 01/2019 - 03/2012
3	Paradoxical Embolism 01/2019 - 01/2007
3	Vitamin B 12 Deficiency (Vitamin B12 Deficiency) 01/2019 - 06/2005
3	Diabetic Nephropathies (Diabetic Nephropathy) 01/2017 - 04/2010
3	Hyperhomocysteinemia 01/2009 - 10/2004
3	Chronic Kidney Failure (Chronic Renal Failure) 01/2009 - 01/2007
2	Bone Fractures (Bone Fracture) 01/2022 - 04/2016
2	Heart Failure 01/2022 - 01/2019
2	Weight Gain 01/2022 - 04/2016
2	Prediabetic State (Prediabetes) 01/2021 - 01/2019
2	Renovascular Hypertension (Goldblatt Syndrome) 10/2020 - 04/2002
2	Chronic Renal Insufficiency 01/2020 - 12/2016
2	Inflammation (Inflammations) 11/2018 - 11/2010
2	Cataract (Cataracts) 11/2016 - 05/2015
2	Lacunar Stroke 10/2016 - 09/2010
2	Cognitive Dysfunction 02/2016 - 01/2013
2	Neoplasms (Cancer) 03/2013 - 10/2010
2	Ulcer 03/2012 - 03/2009
2	Hyperlipidemias (Hyperlipidemia) 11/2010 - 01/2005
2	Cicatrix (Scar) 04/2009 - 06/2004
2	Acute Kidney Injury (Acute Renal Failure) 09/2008 - 04/2002

Drug/Important Bio-Agent (IBA)

32	HomocysteineIBA 01/2022 - 01/2003
22	Vitamin B Complex (B Vitamins)IBA 01/2022 - 04/2010
19	Folic Acid (Vitamin M)FDA LinkGeneric 01/2022 - 01/2003
15	AldosteroneIBA 01/2021 - 01/2007
14	VitaminsIBA 01/2021 - 01/2003
14	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 10/2020 - 01/2003
13	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 01/2022 - 02/2004
12	ReninIBA 01/2021 - 01/2007
12	CholesterolIBA 10/2020 - 08/2002
10	Biomarkers (Surrogate Marker)IBA 01/2022 - 02/2002
9	AnticoagulantsIBA 01/2021 - 08/2007
8	Pioglitazone (Actos)FDA Link 01/2022 - 12/2014
8	LipidsIBA 01/2021 - 07/2003
6	mecobalamin (methylcobalamin)IBA 01/2022 - 02/2016
6	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/2021 - 06/2007
6	Antihypertensive Agents (Antihypertensives)IBA 06/2018 - 01/2003
5	Factor Xa InhibitorsIBA 01/2022 - 12/2018
5	Atorvastatin (Lipitor)FDA Link 10/2017 - 09/2005
4	Platelet Aggregation Inhibitors (Antiplatelet Drugs)IBA 01/2022 - 08/2007
4	Pharmaceutical PreparationsIBA 01/2022 - 05/2008
4	Amiloride (Midamor)FDA LinkGeneric 11/2020 - 05/2010
4	Warfarin (Coumadin)FDA LinkGeneric 01/2019 - 09/2010
4	Insulin (Novolin)FDA Link 01/2019 - 12/2005
4	SodiumIBA 06/2018 - 01/2003
3	Carnitine (L-Carnitine)FDA LinkGeneric 04/2022 - 01/2019
3	Hydroxocobalamin FDA Link 01/2022 - 02/2016
3	trimethyloxamine (trimethylamine N-oxide)IBA 01/2021 - 06/2018
3	oxidized low density lipoproteinIBA 01/2020 - 01/2017
3	Enalapril FDA LinkGeneric 01/2020 - 11/2016
3	Uremic ToxinsIBA 06/2018 - 01/2016
3	Eplerenone (Inspra)FDA LinkGeneric 06/2018 - 05/2010
3	Angiotensin Receptor AntagonistsIBA 06/2018 - 05/2008
3	SaltsIBA 06/2018 - 05/2010
3	OilsIBA 06/2018 - 09/2006
3	Mineralocorticoid Receptor AntagonistsIBA 06/2018 - 05/2010
3	CalciumIBA 01/2018 - 01/2003
3	PotassiumIBA 01/2018 - 01/2003
3	Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)IBA 10/2012 - 04/2002
3	Mesna (Coenzyme M)FDA LinkGeneric 01/2009 - 08/2007
2	Clopidogrel (Plavix)FDA Link 01/2021 - 01/2017
2	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2019
2	Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link 11/2018 - 12/2012
2	Spironolactone (Aldactone)FDA LinkGeneric 06/2018 - 05/2010
2	Nasal Decongestants (Decongestants)IBA 06/2018 - 05/2010
2	Biological ProductsIBA 10/2016 - 06/2004
2	Cyanides (Isocyanides)IBA 10/2016 - 02/2016
2	Nonesterified Fatty Acids (NEFA)IBA 04/2014 - 11/2011
2	LDL Lipoproteins (beta Lipoproteins)IBA 10/2012 - 11/2010
2	Nifedipine (Adalat)FDA LinkGeneric 09/2011 - 06/2007
2	Lipoprotein(a)IBA 03/2010 - 10/2008

Therapy/Procedure

70	Therapeutics 04/2022 - 11/2003
11	Endarterectomy (Thromboendarterectomy) 01/2021 - 03/2014
11	Carotid Endarterectomy 01/2021 - 11/2005
10	Mediterranean Diet 01/2021 - 07/2003
5	Secondary Prevention 01/2022 - 06/2007
3	Renal Dialysis (Hemodialysis) 01/2009 - 10/2004
2	Vegetarian Diet (Vegetarianism) 01/2020 - 06/2018